Supply Chain Risk Assessment for Perishable Products Applying System Dynamics Methodology - A Case of Fast Fashion Apparel Industry

With the fast progress of science and technology and with the continuously growing customer expectations, share of merchandise exhibiting characteristics of perishability is on the rise. Perishable products, through their own nature, are subject to decay, deterioration or obsolescence. As a result, their usefulness, value or functionality is gradually reduced or even lost in a short window of time and cannot be regained if it is not used or sold within a specific time window. When producing perishable products, all stages of the supply chain are exposed to much higher uncertainty than in the case of durable products, which directly means higher risk. The phases of inventory planning, lead time control, and demand forecasting for perishable products play a critical role in the overall effectiveness of the supply chain. For this reason, the system dynamics methodology, a simulation and modeling technique developed specifically to address the long term and dynamic management issues, is adopted in this study. The focus of the proposed model is on the interaction between physical processes, information flows and managerial policies of a three-level supply chain for perishable products, in general, and fast fashion apparel supply chain, in particular, so as to create the dynamics of the variables of interest. The values of supply chain key factors such as, for example, inventory, backlogs, stock-outs, forecast error, cost, and profit for each time period are some of the outputs of the proposed model. Moreover, the Conditional Value at Risk (CVaR) measure is applied to quantify and analyze the risks associated with the supply chain for this type of product and also to determine the expected value of the losses and their corresponding probabilities. With the focus on three prominent categories of risks including risks of delays, forecast, and inventory, multiple business situations for effective strategic planning and decision making are generated and analyzed

Exome sequencing utility in defining the genetic landscape of hearing loss and novel-gene discovery in Iran

Hearing loss (HL) is one of the most common sensory defects affecting more than 466 million individuals worldwide. It is clinically and genetically heterogeneous with over 120 genes causing non-syndromic HL identified to date. Here, we performed exome sequencing (ES) on a cohort of Iranian families with no disease-causing variants in known deafness-associated genes after screening with a targeted gene panel. We identified likely causal variants in 20 out of 71 families screened. Fifteen families segregated variants in known deafness-associated genes. Eight families segregated variants in novel candidate genes for HL: DBH, TOP3A, COX18, USP31, TCF19, SCP2, TENM1, and CARMIL1. In the three of these families, intrafamilial locus heterogeneity was observed with variants in both known and novel candidate genes. In aggregate, we were able to identify the underlying genetic cause of HL in nearly 30% of our study cohort using ES. This study corroborates the observation that high-throughput DNA sequencing in populations with high rates of consanguineous marriages represents a more appropriate strategy to elucidate the genetic etiology of heterogeneous conditions such as HL